The Drug Trial That Went Wrong

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In March 2006, the pharmaceutical world was shaken by the events of the TGN1412 clinical trial that took place at Northwick Park Hospital in north-west London. Initially intended as a potential new treatment for rheumatoid arthritis and certain types of leukaemia, the antibody TGN1412 triggered severe reactions among six of its eight participants. As she examines the impact of the trial on clinical research today, in this programme Dr Margaret McCartney visits a trial centre which is one of the few in the UK licensed to carry out early-stage clinical research.

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